guggestion

Sanjay's answer is wrong on several points. Do not use ignorant people in place of less-educated people.  It is insulting.  

Affluence is a noun and the wrong word.  It should be affluent, an adjective.

Replacing the comma with the word "and" when using multiple descriptive adjectives changes the meaning of the sentence.  When you use the comma in this case, it describes people who are both affluent and well-educated.  When you use "and" instead, it changes to two sets of people:  affluent people and well-educated people. Affluent people might not be well educated, and well-educated people might not be affluent. 

Affluent, well-educated people live longer than those with less education and lower incomes.